Uhm hello! Are you waiting too or is it just me? :D

I'm here!

Good morning!

Nice nice

Goodmorning!

Have you already thought about things you want to ask?

yes, I have 1 question about transposome

Is it about the topic of the last test, the one that wasn't in the textbooks?

I wanted to ask if the textbook 2 would be talked about in the next lesson

Maybe you know^

No, it's a curiosity about tumor

How many hours do you all usually take to read a reviev?

Because I always take so much to study it and I don't know if it's normal XD

too much, 3-4 hours, it's because i have to check a lot of word

Yeah me too

Well, it relieves me knowing I'm not the only one

The only articles I read quickly are those of Koreans, in my opinion they have a sentence structure similar to the Italian one

That's really interesting! Ahahaha

From now on I'll look forward to study from korean articles

guys can you explain abiut the graphs of the lenght of introns and exons

Sure, we'll try. What's your doubt?

i am a bit confused abiut this part in the video

the first things that I want to know that is it directly proportional to the complexity

i mean the lenghth of introns and exons

both of them

Yeah. They're directly proportional because you have to think about alternative splicing

More introns --> More alternative splicing possibilities --> More proteins to be made from the same gene of the same length --> More complexity of the organism

also, for the length of exons I have to just comsider the horizontal

because it is not mentioned about vertical

Okay just let me go back to the lesson because I don't get what do you mean for orizontal and vertical

Do you mean the x and y axes of the graph?

If you have a gene with 20 exons, it's possible that you create different constructs by skipping exons, the length of the introns instead I think is irrelevant. Last night we talked about that picture, remember? the 3 proteins originated from the same gene, but with different splicing. if you think that from a gene with 6 exons you can already get a 3 isoform protic, think with one of 20

if I am not misteaken the 2 other species are extended in the horizontal but human is extended in the vertical in the

protein isoforms*

yes daniela

Oky I got your question

The graph shows a frequency distibution

On the vertical axe you have the frequency, shown as a percentage

On the x axe you have the exon lenght

The curves reach the highest point at the exon lenght that is more present in the genome of that animal

You see the frequency curve of Homo sapiens is more high because homo sapiens has got many exons of quite the same lenght (in particularly, of 100 bp, that is where the peak is)

ok

While the other two animals also has got a few number ox exon that are much longer (even 600 bp)

And what about the x axe of intron length

So they're distributed more homogenously through all the possible lenghts

It's the same for Intron graph, but instead of using a continous curve, you're using single rectangles

If you join the top of each rectangle, you'll obtain a curve, for each animal

for introns x axe it means that the introns length between 100-2000 kb is much higher than the other parts

just it?

am I undrestood correctly or not?

Yes, or better, it means that humans have got the majority of Introns that are 100-2'000 bp long

okay

While for example C.elegans, the blue rectangle, has got the majority of Introns <100 bp long

thank you of both of you guys

of introns <100 bo long

oh god it doesn't let me write

I got it

*of introns less than 100 bo long (finally! ahahaha)

Good ^_^