Course: Forensic Genetics and Legal Medicine

General

Announcements Forum
15th, 20th, 22nd, 27th, 29th April 2020 16:00 - 18:00 Lectures Aula C Dipartimento di Scienze della Vita e Biologia dei Sistemi - sede di via Accademia Albertina 13 (if not possible, online)

4th, 6th, 11th, 13th, 18th, 20th, 25th May 2020 16:00 - 18:00 Lectures Aula C Dipartimento di Scienze della Vita e Biologia dei Sistemi - sede di via Accademia Albertina 13 (if not possible, online)

5th May 2020 14:00 - 1:00 Workshop (software for forensic human identification) Aula 4 Dipartimento di Scienze della Vita e Biologia dei Sistemi - sede di via Accademia Albertina 13 (if not possible, online)

12th May 2020 14:00 - 17:00 Workshop (software for paternity and kinship testing) Aula 4 Dipartimento di Scienze della Vita e Biologia dei Sistemi - sede di via Accademia Albertina 13 (if not possible, online)

19th May 2020 14:00 - 17:00 Workshop (big data in forensics) Aula 4 Dipartimento di Scienze della Vita e Biologia dei Sistemi - sede di via Accademia Albertina 13 (if not possible, online)

26th May 2020 14:00 - 17:00 Workshop (genetic genealogy and DTC tests) (on line)

Introductory info

DNA polymorphisms in forensics

Standard typing techniques

Standard typing techniques - Part I URL
Standard typing techniques - Part II URL
Standard typing techniques - Part I&II File
Supplementary material - Standard typing techniques Folder
Material includes:
- a general review on STR typing by capillary electrophoresis
- a paper describing SBE and forensic applications of SNPs (several arguments such as ancestry inference and phenotyping will be covered in following lessons)
- the first paper describing forensic use of Indels
Standard typing techniques Quiz

NGS in forensics

Basic match interpretation (population genetics)

Basic match interpretation (Y-STR, mtDNA) + advanced match interpretation

Kinship testing (standard paternity testing)

Beyond identification (intro and sex-typing)

Workshop (software for forensic identification)

Workshop (software for forensic identification) part I URL
Workshop (software for forensic identification) pt II URL
Supplementary material - Workshop (software for forensic identification) Folder
Exercises (software for forensic identification) Assignment
Use LRmix and Euroformix to interpret DNA samples provided in the exercise 1 and 2 sub-folders of supplementary material.
Follow the instructions included in subfolders (NB please notice that in Euroformix Exercise 2 a further penalization score is applied when 3 contributors are assumed instead of 2).
Provide the results either as .doc files, filling the yellow spaces in the instructions files of each exercise, or as separated LRmix and Euroformix report files for each exercise/assignement within exercise.
For self evaluation, correrct results of the exercises will be uploaded on Moodle after due date (19th May 2020).
The sole purpose of these exercises is -for you- to gain experience with forensic genetics software, and -for me- to assess the effectiveness of my presentations. Submission of the results is not mandatory and submitted results will not be used for your final evaluation.
Solutions (Exercise 1 and 2) Folder

Beyond identification (ancestry inference)

Kinship testing (complex cases)

Workshop (software for kinship testing)

Workshop (software for kinship testing) pt Ia URL
Due to audio recording problems, the presentation stops abruptly at minute 28.10, please proceed to pt Ib for the following part of the presentation
Workshop (software for kinship testing) pt Ib URL
Workshop (software for kinship testing) pt II URL
Supplementary material - Workshop (software for kinship testing) Folder
Exercises (software for kinship testing) Assignment
Use Familias and FamlinkX to interpret DNA samples provided in the exercise 1 and 2 sub-folders of supplementary material.
Follow the instructions included in the woorkbook (.ppt)
Provide the results either as .doc files, filling the yellow spaces in the module provided as supplementary material, or as separated Familias and FamlinkX report files for each exercise/assignement within exercise.
For self evaluation, correrct results of the exercises will be uploaded on Moodle after due date (25th May 2020).
The sole purpose of these exercises is -for you- to gain experience with forensic genetics software, and -for me- to assess the effectiveness of my presentations. Submission of the results is not mandatory and submitted results will not be used for your final evaluation.
Solutions (exercise 1 and 2) Folder

Beyond identification (externally visible characteristics, activity level)

Stain detection and body fluid identification, DNA isolation and quantitation

Population genetics and ancestry inference software

Population genetics and ancestry inference software - PART 1 URL
Population genetics and ancestry inference software - PART 2 URL
Population genetics and ancestry inference software - PART 3 URL
Files for the tutorial Folder
This directory contains the files you need to download on your computer in a folder called "popgen_tutorial".
Population genetics and ancestry inference software File
This file is the popgen_tutorial.html I have shown you in the videos.
Supplementary Materials - Population genetics and ancestry inference software Folder
Exercises - Population genetics and ancestry inference software Assignment

Forensic pathology

Forensic pathology - Intro URL
Forensic pathology - Thanatology URL
Forensic pathology - Traumatology I URL
Forensic pathology - Traumatology II + Burns URL
Forensic pathology - Sharp-force injuries and gunshot wounds URL
Forensic pathology - Asphyxia URL
Forensic pathology File
Supplementary material - Forensic pathology File
Review on time of death estimation
Supplementary material - Forensic pathology URL
link to e-book resource "Jason Payne-James, Richard Jones, Steven Karch, and John Manlove. Simpson's forensic medicine, CRC Press LLC 2011"
If the link does not work, please follow the path: https://www.bfm.unito.it/it/che-cosa-cerchi/e-book > Trova_UniTO: E-books > write in the "inserisci titolo o ISBN" search box: "Simpson's forensic medicine" and then follow the link
Supplementary material - Forensic pathology URL
link to e-book resource "Charles Catanese. Color Atlas of Forensic Medicine and Pathology, Taylor & Francis Group 2009"
If the link does not work, please follow the path: https://www.bfm.unito.it/it/che-cosa-cerchi/e-book > Trova_UniTO: E-books > write in the "inserisci titolo o ISBN" search box: "Color Atlas of Forensic Medicine and Pathology" and then follow the link
Forensic pathology Quiz

Workshop (forensic genetic genealogy)

Crime scene investigation and the Italian criminal DNA database

WRITTEN TEST 26.6.2020

WRITTEN TEST 26.6.2020 Quiz
The test consists of 15 multiple choice questions. Each question has 5 answers (only one correct). Correct answers will give 2 points; wrong answers 0 points (no penalization).
Time limit to perform the test is 12 minutes. The test will be open between 10.30 AM and 11.00 AM of 26.6.2020. Time limit to perform the test is 12 minutes and only one attempt is allowed.
Written test scores will be confirmed (or increased/decreased of maximum 2 points, according to performance) after oral examination.
NB please remember to have the PC/pocket calculator ready before starting the written test, since it could be useful to answer some of the questions!

WRITTEN TEST 20.7.2020

WRITTEN TEST 20.7.2020 Quiz
The test consists of 15 multiple choice questions. Each question has 5 answers (only one correct). Correct answers will give 2 points; wrong answers 0 points (no penalization).
The test will be open between 10.30 AM and 11.00 AM of 20.7.2020 (Central European Time). Time limit to perform the test is 12 minutes and only one attempt is allowed.
Written test scores will be confirmed (or increased/decreased of maximum 2 points, according to performance) after oral examination.
NB please remember to have the PC/pocket calculator ready before starting the written test, since it could be useful to answer some of the questions!
WRITTEN TEST 29.9.2020 Quiz
The test consists of 15 multiple choice questions. Each question has 5 answers (only one correct). Correct answers will give 2 points; wrong answers 0 points (no penalization).
The test will be open between 10.30 AM and 11.00 AM of 29.9.2020 (Central European Time). Time limit to perform the test is 12 minutes and only one attempt is allowed.
Written test scores will be confirmed (or increased/decreased of maximum 2 points, according to performance) after oral examination.

WRITTEN TEST 13.11.2020

WRITTEN TEST 13.11.2020 Quiz
The test consists of 15 multiple choice questions. Each question has 5 answers (only one correct). Correct answers will give 2 points; wrong answers 0 points (no penalization).
The test will be open between 10.00 AM and 10.30 AM of 13.11.2020 (Central European Time). Time limit to perform the test is 12 minutes and only one attempt is allowed.
Written test scores will be confirmed (or increased/decreased of maximum 2 points, according to performance) after oral examination.

WRITTEN TEST 28.1.2021

WRITTEN TEST 28.1.2021 Quiz
The test consists of 15 multiple choice questions. Each question has 5 answers (only one correct). Correct answers will give 2 points; wrong answers 0 points (no penalization).
The test will be open between 14.00 PM and 14.30 AM of 28.1.2021 (Central European Time). Time limit to perform the test is 12 minutes and only one attempt is allowed.
Written test scores will be confirmed (or increased/decreased of maximum 2 points, according to performance) after oral examination.

Topic outline