Topic outline
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Starting from the fact that a new complex organism originates from a single totipotent stem cell (the zygote) through development, and tissue specific differentiated cells can arise from single pluripotent stem cells, you will be guided to reflect on the very basic cellular mechanisms underlying such processes. You will read about cell differentiation, specification, determination, fate and commitment ...
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TASK - reading articles 1.
1. read the article by Harrison et al., 2017 following suggestions you will find in the file notes on scientific articles;
2. take notes that will be useful to discuss the article during the lesson on Wednesday - March 14;
3. identify terms used in the article that are new for you and create a glossary (max 10 terms each student)
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In this article published on Science (March 2, 2017) researchers describe how, using a combination of genetically-modified mouse ESCs and TSCs, together with a 3D scaffold known as an extracellular matrix, they were able to grow a structure capable of assembling itself and whose development and architecture very closely resembled the natural embryo