Topic outline
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The main objective of the material proposed this week is focussed on neural progenitors. To this aim you will have to work on the material on the start@unito platform Unit 4 - Section 1.
- watch the video on Neural Progenitors
- read the instant notes on neural progenitor potential and generation of cell diversity
- in the external resources: visit Michèle Studer lab website
- perform the task described below (dead line May 4)
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Read the original articles that were at the basis of the discovery of RGCs as neural stem progenitor cells, paying particular attention to the experimental approaches used (in vivo? ex vivo? in vitro?; tissue or dissociated cells?), compare them and think about the main advantages and possible limits of each approach.
Write a short report (600 words max) summarizing your thoughts on this topic.
· Malatesta, P., Hartfuss, E. and Götz, M. (2000). Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development 127, 5253-5263. https://www.ncbi.nlm.nih.gov/pubmed/11076748
· Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S. and Kriegstein, A. R. (2001). Neurons derived from radial glial cells establish radial units in neocortex. Nature 409, 714-720.https://www.ncbi.nlm.nih.gov/pubmed/11217860
· Miyata, T., Kawaguchi, A., Okano, H. and Ogawa, M. (2001). Asymmetric inheritance of radial glial fibers by cortical neurons. Neuron 31, 727 741.https://www.ncbi.nlm.nih.gov/pubmed/11567613
deadline for the submission May 4
deadline for the peer review May 8
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