Copy and past the following questions and use telegraphic style (omitting articles, pronouns, conjunctions, transitions, and other sentence structures) in your answers.

What did you learn from the remote readings and materials? (indicate, according to your personal background, which information from the remote materials is the most useful to you and your take home messages. There is no right or wrong answer. 

......

What did you learn from paper 02? (This will help you participating to paper discussion during the lecture).

Answer the following questions:

1. What is imatinib? How does it work?.......
2. What was the motivation for conducting this study?.......
3. Describe the processes involved in protein folding. What can change the three-dimensional (3D) structure of a protein?......
4. How can scientists determine the 3D structure of a protein? .....Is there a disadvantage to this type of analysis? ...... 
5. Why was it so important for the authors to know the 3D structure of Bcr-Abl protein bound to imatinib in order to conduct this study?.........
6. The authors identify a good candidate, BMS-354825, that might be able to inhibit imatinib-resistant forms of Bcr-Abl. What did they find in Figure 2?......
7. Do their data support BMS-354825 as a clinically relevant therapy for CML patients who have become resistant to imatinib? ...... (Explain your answer).
8. Which aspect of Paper 02, if any, is the most:
1. interesting to you? .....
2. difficult to you ....  
9. What additional experiments would you perform to follow up on this work? .......

Note: Evaluation (excellent to poor) is according to commitment and response elaboration, not a matter of length of the response. Stay focused.