Dear students, if you don't find highlighted the city you are from, please send me the name of the city (and the country) by mail and I will add it. Sincerely, Giovanna

Adopted Textbook: Molecular Biology of the Cell B. Alberts, WWNorton editor

Code discount for students of this course at www.wwnorton.co.uk:

• 25% off print: BTU20
• 10% off eBooks: EK10

Textbook Readings:

• Chapter 03: Proteins (Protein modifications, Functions of proteins)
• Chapter 8 Analyzing cells and molecules
  
• Chapter 9 Visualizing cells (Fluorescence microscopy, fluorescence recovery after photobleaching (FRAP), RNAi; Confocal microscopy) 
• Chapter 16: Cytoskeleton (Cell polarization and migration)
• Chapter 17 Cell Cycle
• The DNA damage response and later
• Chapter 19: Cell junctions and the Extracellular matrix (Cell matrix junctions
• Chapter 20 Cancer
• Mutations in the p53 Pathway Enable Cancer Cells to Survive and Proliferate Despite Stress and DNA Damage

• Readings from Nature Education:

  • Cell Cycle Control by Oncogenes and Tumor Suppressors: Driving the Transformation of Normal Cells into Cancerous Cells (html)

  • p53 : The Most Frequently Altered Gene in Human Cancers (html)

general and practical informations about antibody production

basic techniques

Hirata H et al., Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions 

Shah NP et al., Overriding imatinib resistance with a novel ABL kinase inhibitor, Science. 2004, 305:399-401.

A series of lectures by Brian Druker on the iBiology Web site related to imatinib

Grebien F et al., Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell. 2011,147:306-19

Ingallina et al. (2018) Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis. Nature Cell Biology, 20: 28–35 

to partecipate insert code: ACBBPAPER4

Due by Sunday December 12th, to be discussed on Monday 13th lecture

Please find attached the sequences of the different NRG1 domains. I kindly ask you to verify if your domain sequences are correct. If you included also the 5'UTR your numbers will be different, but the sequence should be the same.  I also included Annhyb pictures, to show you how you can organize domain information with this tool.  In the exercize I was asking the length of the EGF-like sequence, not the sequence, don't worry if you included the sequence!

You have to add A or AA to obtain B and C vectors.